Fig. 4: The crosstalk between necroptosis, pyroptosis, and ferroptosis.
From: Non-coding RNAs in necroptosis, pyroptosis and ferroptosis in cancer metastasis
Several studies showed that there is an interaction between necroptosis, pyroptosis, and ferroptosis. RIP1 or RIP3-mediated necroptosis contributes to the membrane damage. Potassium ion outflow activates NEK7, which leads to the cleavage of GSDMD. Additionally, Iron activates ROS for GSDME-dependent pyroptosis in melanoma cells, suggesting there is a crosstalk between ferroptosis, pyroptosis and necroptosis.
