Fig. 6: The mechanistic diagram.

HDAC4 down-regulates the expression of miR-206 to promote cardiomyocyte apoptosis and oxidative stress, thereby inducing MIRI by activating MEKK1/JNK pathway.
HDAC4 down-regulates the expression of miR-206 to promote cardiomyocyte apoptosis and oxidative stress, thereby inducing MIRI by activating MEKK1/JNK pathway.