Fig. 4: Differential enrichment of genes related to metabolism and cell death pathways in MDA-MB-231 cells with BCKDK knockdown. | Cell Death Discovery

Fig. 4: Differential enrichment of genes related to metabolism and cell death pathways in MDA-MB-231 cells with BCKDK knockdown.

From: Inhibiting BCKDK in triple negative breast cancer suppresses protein translation, impairs mitochondrial function, and potentiates doxorubicin cytotoxicity

Fig. 4

A Principle component analysis plot for all gene expressions from MDA-MB231 cells treated with both siRNAs targeting BCKDK. B Distance matrix clustering for all gene expressions from MDA-MB231 cells. C Heatmap for differentially expressed genes from MDA-MB231 cells. D Top 20 most significantly enriched gene ontology (GO) terms from BCKDK knockdown induced differentially expressed genes. Color represents the fold enrichment statistic, and size represents the percentage of the differentially expressed genes in the gene set compared with the total gene set size. E Heatmap for genes involved in apoptosis which were significantly differentially regulated by BCKDK knockdown in MDA-MB231 cells.

Back to article page