Fig. 7: Research summary: circulating mature DCs homing to the thymus promote thymic epithelial cell involution through the Jagged1/Notch3 axis. | Cell Death Discovery

Fig. 7: Research summary: circulating mature DCs homing to the thymus promote thymic epithelial cell involution through the Jagged1/Notch3 axis.

From: Circulating mature dendritic cells homing to the thymus promote thymic epithelial cells involution via the Jagged1/Notch3 axis

Fig. 7

Circulating mDCs can return to the thymus where they interact with TECs through direct cell–cell contact. MDCs can activate Notch signaling in TECs through the Jagged1/Notch3 axis. Long-term Notch signaling activation of TECs results in apoptosis and growth inhibition, further leading to the degeneration of the thymus.

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