Fig. 5: MSC-EVs administration restores the hippocampal neuronal morphology and function in mice. | Cell Death Discovery

Fig. 5: MSC-EVs administration restores the hippocampal neuronal morphology and function in mice.

From: Tail-vein injection of MSC-derived small extracellular vesicles facilitates the restoration of hippocampal neuronal morphology and function in APP / PS1 mice

Fig. 5

A Images show the 3D reconstruction of dendritic spine and dendritic phenotype for the hippocampal neurons in the WT, AD + saline, and AD + EVs group (left bar = 50 μm; right two bars = 15 μm). B–E Imaris analysis of spines along basal dendrites including total spine density (B), filopodia spine density (C), mushroom spine density (D), and long thin spine density (E) of three groups. F, G Statistical analysis of total dendritic length (F) and dendritic intersections (G) in the panel. H Trace images show the waveform of the pyramidal neurons in each group. I–K Histogram represent the statistical data of half-width (I), neuronal membrane potential (MP) (J), and action potential (AP) frequency (K) in each group (n = 15 per group). The values represent as Mean ± SEM. The data meet normal distribution and the variance is homogeneous. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

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