Fig. 6: Oxidative defense system is associated with the EVs therapy in APP/PS1 mice. | Cell Death Discovery

Fig. 6: Oxidative defense system is associated with the EVs therapy in APP/PS1 mice.

From: Tail-vein injection of MSC-derived small extracellular vesicles facilitates the restoration of hippocampal neuronal morphology and function in APP / PS1 mice

Fig. 6

A Western blots of nuclear factor E2-related factor 2 (Nrf2) signaling and oxidative marker inducible nitric-oxide synthase (iNOS) in the animal models. B–F Statistical analysis of the relative expression of Nrf2 (B), Keap1 (C), HO-1 (D), iNOS (E), and NQO1 (F) in the WT, AD + saline, and AD + EVs groups mice (n = 5 per group). G Western blots of Nrf2 signaling and iNOS in APPwt, APPswe + PBS, and APPswe + EVs groups. H–L Statistical analysis of the relative expression of Nrf2 (H), Keap1 (I), HO-1 (J), iNOS (K), and NQO1 (L) in cell models. The values represent Mean ± SEM. The data meet normal distribution and the variance is homogeneous. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

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