Fig. 6: Schematic of the mechanism of sitagliptin in improving liver inflammation. | Cell Death Discovery

Fig. 6: Schematic of the mechanism of sitagliptin in improving liver inflammation.

From: Dipeptidyl peptidase-4 (DPP4) inhibitor sitagliptin alleviates liver inflammation of diabetic mice by acting as a ROS scavenger and inhibiting the NFκB pathway

Fig. 6

Specifically inhibiting the activity of DPP4 in hepatocytes by sitagliptin contributes to decreased activation of NFκB pathway and oxidative stress, as well as cell apoptosis under diabetic conditions. The ROS cleaning function of sitagliptin promotes the deactivation of NFκB pathway.

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