Fig. 3: The circβ-catenin promotes cell cycle progression in vitro and tumor growth in vivo. | Cell Death Discovery

Fig. 3: The circβ-catenin promotes cell cycle progression in vitro and tumor growth in vivo.

From: Circβ-catenin promotes tumor growth and Warburg effect of gallbladder cancer by regulating STMN1 expression

Fig. 3

A, B Flow cytometry analysis was shown as the percentage cell phase distribution including G0/G1, S, and G2/M phases after transfection of NOZ and SGC-996 cells with shRNA-NC, shRNA-1, or shRNA-2. C Flow cytometry analysis was shown as the percentage cell phase distribution including G0/G1, S, and G2/M phases after transfection of GBC-SD cells with pLCDH-vector or pLCDH-circβ-catenin. D Nude mice were subcutaneously injected with Lv-shRNA-NC cells or cells transfected with Lv-sh-circβ-catenin, after 4 weeks, tumors were dissected and imaged. E Tumor weight or volume was detected to monitor tumor growth in subcutaneous implantation mouse models transfected with Lv-shRNA-NC cells or cells transfected with Lv-sh-circβ-catenin. F Immunohistochemical staining of Ki-67 expression was shown in tumor tissues in Lv-shRNA-NC or Lv-sh-circβ-catenin group (original magnification, ×200). Data are shown as mean ± SD. *P < 0.05, **P < 0.01.

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