Fig. 3: B7-H5 inhibition suppressed tumor growth in mice and promoted CD8+ T-cell infiltration in the tumor tissues of MC38 model.
From: B7-H5 blockade enhances CD8+ T-cell-mediated antitumor immunity in colorectal cancer
A Growth curve of MC38 tumors after treatment with monoclonal anti-mouse B7-H5 antibody (B7-H5 mAb) or control IgG. n = 7. The experiments were performed in triplicate. Values are expressed as means (SEMs). **P < 0.01. B The proportion of CD3+ T and CD8+ T cells in tumor tissues from MC38 tumors after treatment with B7-H5 mAb or control IgG was analyzed by immunofluorescence (original magnification ×200). A representative image was shown. n = 4. The experiments were performed in triplicate. Values are expressed as means (SD). *P < 0.05; **P < 0.01. C The proportion of CD8+ T cells in the CD45+ T cells of tumor tissues from MC38 tumors after treatment with B7-H5 mAb or control IgG was analyzed by flow cytometry. A representative image was shown. n = 4. The experiments were performed in triplicate.
