Fig. 1: Expression of NEAT1 is upregulated and miR-139-5p is downregulated in liver fibrosis. | Cell Death Discovery

Fig. 1: Expression of NEAT1 is upregulated and miR-139-5p is downregulated in liver fibrosis.

From: miR-139-5p sponged by LncRNA NEAT1 regulates liver fibrosis via targeting β-catenin/SOX9/TGF-β1 pathway

Fig. 1

A The expression of NEAT1 was upregulated in human liver fibrosis tissues. n = 30/group. B The expression level of miR-139-5p was downregulated in human liver fibrosis tissues. n = 30/group. C The correlation between NEAT1 and miR-139-5p expression levels in fibrotic liver tissues from patients was evaluated with Pearson’s correlation analysis, n = 30. D The liver tissues from mice treated with CCl4 for 8 weeks and BDL for 2 weeks were performed with Masson staining and Sirius red staining. n = 6/group, original magnification×200. E The expression level of NEAT1 was upregulated and the expression level of miR-139-5p was downregulated in murine liver fibrosis tissues. n = 6/group. F The expression level of NEAT1 was upregulated in activated LX-2 cells stimulated with 10 ng/mL TGF-β1 in a time-dependent manner. n = 6/group. G The expression level of miR-139-5p was decreased in activated LX-2 cells stimulated with 10 ng/mL TGF-β1 in a time-dependent manner. n = 6/group. Graph represents mean ± SD. *P < 0.05, **P < 0.01.

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