Fig. 4: Cooperative treatment effects of ATO and PARP inhibitors on cell apoptosis in SKOV3 and CAOV3 cells. | Cell Death Discovery

Fig. 4: Cooperative treatment effects of ATO and PARP inhibitors on cell apoptosis in SKOV3 and CAOV3 cells.

From: Arsenic compound sensitizes homologous recombination proficient ovarian cancer to PARP inhibitors

Fig. 4

ATO and PARP inhibitors, niraparib, olaparib, or fluazolepali, cooperatively induced apoptosis of SKOV3 and CAOV3 cells. Cells were treated with DMSO, ATO, niraparib, olaparib, fluazolepali, combination of ATO and niraparib, combination of ATO and olaparib, or the combination of ATO and fluazolepali for 48 h, followed by FACS analysis of cell apoptosis with annexin V and PI staining. We used the IC50 of each drug for this experiment. Representative images of three biologically independent experiments. Error bars represent mean ± SD. NS not significant; *P < 0.05; **P < 0.01.

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