Fig. 5: ATO cooperates with PARP inhibitors to induce cleaved-PARP and γH2AX expression and inhibits phosphor-AKT expression. | Cell Death Discovery

Fig. 5: ATO cooperates with PARP inhibitors to induce cleaved-PARP and γH2AX expression and inhibits phosphor-AKT expression.

From: Arsenic compound sensitizes homologous recombination proficient ovarian cancer to PARP inhibitors

Fig. 5

SKOV3 (A) and CAOV3 (B) cells were treated with DMSO, ATO, niraparib, olaparib, fluazolepali, combination of ATO and niraparib, combination of ATO and olaparib, or the combination of ATO and fluazolepali for 72 h, followed by assaying total PARP, cleaved-PARP, total AKT, phosphor-AKT, and γH2AX by western blotting. β-actin loading as control. The shown blots are of samples derived from the same experiment. Representative of n = 3 biologically independent experiments. Error bars represent mean ± SD. NS not significant; *P < 0.05; **P < 0.01.

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