Table 2 Applications of tsRNAs in cancer diseases.
From: tRNA-derived small RNAs: novel regulators of cancer hallmarks and targets of clinical application
| Â | tsRNA | Cancer type | Characteristics | Reference |
|---|---|---|---|---|
Single tsRNAs as biomarkers or therapeutic targets | tRNA-ValTAC-3 | Liver cancer | All upregulating | [76] |
tRNA-Gly-TCC-5 | Â | |||
tRNA-Val-AAC-5 | Â | |||
tRNA-Glu-CTC-5 | Â | |||
tRF-Leu-CAG | NSCLC | Upregulating | [45] | |
tRF-30-JZOYJE22RR33 | Breast cancer | Upregulating | [77] | |
tRF-27-ZDXPHO53KSN | Â | |||
tDR-0009 tDR-7336 | TNBC | Upregulating | [95] | |
tRF-32-XSXMSL73VL4YK tRF-32-Q99P9P9NH57SJ tRF-17-79MP9PP | Breast cancer | Upregulating | [96] | |
Downregulating | Â | |||
Downregulating | Â | |||
miR-21-5p miR-23a-3p tRF-Lys | Breast cancer | All upregulating | [97] | |
tRF-Glu-CTC-003 tRF-Gly-CCC-007 tRF-Gly-CCC-008 tRF-Leu-CAA-003 tRF-Ser-TGA-001 tRF-Ser-TGA-002 | Breast cancer | All downregulating | [98] | |
ts-34 ts-49 | Breast cancer | Low level of ts-34 or a high level of ts-49 showed improved survival | [99] | |
miR-122-5p miR-142-3p 5′tRNA4-Val-AAC | Clear cell renal cell carcinoma | Upregulating | [100] | |
Upregulating | Â | |||
Downregulating | Â | |||
Multiple tsRNA expression signatures as risk factors | tRNALysCTT tRNAPheGAA | Prostate cancer | Upregulating | [101] |
Downregulating | Â |
