Fig. 3: The Hh pathway regulates apoptosis through Rdx.
From: The Hh pathway promotes cell apoptosis through Ci-Rdx-Diap1 axis
a A control eye disc was stained to show GFP (green), Ci (blue), and rdx-lacZ (red). Of note, rdx-lacZ expresses in the posterior region of the eye disc. b Overexpression of ci activated rdx-lacZ expression in the eye disc. c Ci was able to turn on rdx-lacZ expression in the wing disc. Compared to the control eye (d), knockdown of rdx elevated GMR-hid eye (e), while overexpression of rdx decreased GMR-hid eye (f). g Overexpression of rdx-Δ3box failed to affect GMR-hid eye. h Deletion one copy of endogenous rdx increased GMR-hid eye. i Quantification analyses of d–h eye sizes (n = 15). Scale bars: 50 μm for all disks and 200 μm for all adult eyes.
