Fig. 7: PP suppressed GBM xenograft growth and was synergized with TMZ in vivo. | Cell Death Discovery

Fig. 7: PP suppressed GBM xenograft growth and was synergized with TMZ in vivo.

From: Pyrvinium pamoate regulates MGMT expression through suppressing the Wnt/β-catenin signaling pathway to enhance the glioblastoma sensitivity to temozolomide

Fig. 7

A Typical mouse bioluminescence images at 13, 22, 28 and 34 days following GBM cell implantation. B The bioluminescence images were quantitatively analyzed for four experimental groups (n = 5). *p < 0.05; ****p < 0.001. C Representative images of HE-stained brain sections in PP and control group. D Kaplan−Meier survival curves for the four experimental groups (n = 5). E Representative images of TUNEL staining in PP and control group. The scale bar is 10 µm. F The protein levels of p-AKT, p-GSK3β (S9), MGMT, and β-catenin were evaluated through western blotting within orthotopic GBM xenograft (n = 3). The results were displayed in the manner of mean ± SD. *p < 0.05 vs. control group; #p < 0.05 vs. single group.

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