Fig. 2: Overexpression of COL5A1 correlates with poor survival in glioma patients.

A Scores (0–3) indicate COL5A1 levels in representative glioblastoma tumor tissues. B Expression level of the COL5A1 protein in tumor tissue compared to that in corresponding normal adjacent tissue. C Kaplan–Meier overall survival curve of 63 glioma patients stratified according to a high or low COL5A1 protein expression level (p = 0.031). D A forest plot was generated with the hazard ratio and 95% confidence interval (CI) of the COL5A1 expression level in various clinical cohorts. E A forest plot was generated with the hazard ratio and 95% confidence interval (CI) of the COL5A1 expression level according to various clinicopathological factors in an existing cohort. The significance of the differences in (C) was analyzed using Student’s t test.