Fig. 8: Electrophysiological damage of sciatic nerves in MPTP-administrated mice with amelioration in CU-CPT22 + MPTP group. | Cell Death Discovery

Fig. 8: Electrophysiological damage of sciatic nerves in MPTP-administrated mice with amelioration in CU-CPT22 + MPTP group.

From: Phosphorylated α-synuclein aggregated in Schwann cells exacerbates peripheral neuroinflammation and nerve dysfunction in Parkinson’s disease through TLR2/NF-κB pathway

Fig. 8

Mice were tested 4 days after the last MPTP administration. A Representative electrophysiology of sciatic nerves for saline, MPTP, CU-CPT22 + MPTP and CU-CPT22 groups. B Stimulus-amplitude response curve in the four groups. C Quantitative analysis of latency, SNAP amplitude and NCV under a certain stimulus (3.5 mV) in the four groups. Data were presented as mean ± SEM and analyzed by one-way ANOVA followed by Tukey’s post hoc test; n = 11. **p < 0.01 vs. saline group; #p < 0.05, ##p < 0.01 vs. MPTP group. MPTP: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; SNAP: sensory nerve action potential; NCV: nerve conduction velocity; SEM: standard error of the mean; ANOVA: analysis of variance.

Back to article page