Fig. 1: Upregulated circCOG2 in CRC is correlated with poor prognosis. | Cell Death Discovery

Fig. 1: Upregulated circCOG2 in CRC is correlated with poor prognosis.

From: Exosome-transmitted circCOG2 promotes colorectal cancer progression via miR-1305/TGF-β2/SMAD3 pathway

Fig. 1

A Dysregulated circRNAs in CRC tissues compared with normal tissues (CRC: colorectal cancer; CRC_NT: adjacent non-tumor tissues; CRC_rep: normal mucosa tissues). B The gene loci of COG2 and exon 4 and 5 formed circCOG2. C Sanger sequence showing the splicing site of circCOG2. D The expression level of circCOG2 and GAPDH after RNase R treatment. E Expression of circCOG2 in tumor and normal tissues. F Expression of circCOG2 in plasma isolated from CRC patients and healthy people. G Expression of circCOG2 in preoperative and postoperative plasma of CRC patients. H Survival curve of CRC patients with high circCOG2 expression and low circCOG2 expression. I The AUC of circCOG2, CEA, CA19-9, and CA 72-4. ****P < 0.0001; P-values were calculated by Student’s t-test.

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