Fig. 2: circCOG2 promotes CRC proliferation, migration, and invasion in vitro. | Cell Death Discovery

Fig. 2: circCOG2 promotes CRC proliferation, migration, and invasion in vitro.

From: Exosome-transmitted circCOG2 promotes colorectal cancer progression via miR-1305/TGF-β2/SMAD3 pathway

Fig. 2

A, C and E CCK8 and colony formation assays indicated that knockdown of circCOG2 inhibited CRC cells proliferation. B, D and F CCK8 and colony formation assays indicated that overexpression of circCOG2 promoted CRC cells proliferation. G–J Transwell assay indicated that knockdown of circCOG2 inhibited CRC cells migration and invasion. K–N Transwell assay indicated that overexpression of circCOG2 promoted CRC cells migration and invasion. O–Q Wound healing assay indicated that knockdown of circCOG2 inhibited CRC cells migration. R–T Wound healing assay indicated that overexpression of circCOG2 promoted CRC cells migration. U Western blot showed that the expression of vimentin and E-cadherin was decreased and increased, respectively, in CRC cells with circCOG2 knockdown. V Western blot showed that the expression of vimentin and E-cadherin was increased and decreased, respectively, in CRC cells with circCOG2 overexpression. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001; P-values were calculated by Student’s t-test.

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