Fig. 3: miR-1305 is the target of circCOG2. | Cell Death Discovery

Fig. 3: miR-1305 is the target of circCOG2.

From: Exosome-transmitted circCOG2 promotes colorectal cancer progression via miR-1305/TGF-β2/SMAD3 pathway

Fig. 3

A Cytoplasm and nuclear fractions indicated that circCOG2 was located in the cytoplasm. B The illustration showed the binding site of four miRNAs with circCOG2. C The expression of four miRNAs in circCOG2 knockdown or overexpression cells. D The expression of miR-1305 in CRC and normal tissues. E The expression of miR-1305 was negatively correlated with the expression of circCOG2. F The illustration of the dual-luciferase reporter plasmid. G The luciferase activity of circCOG2-WT or circCOG2-MUT transfected with miR-1305 or miR-NC. H CircCOG2 probe pull more miR-1305 than oligo probe. I MiR-1305 pulled more circCOG2 than miR-NC. *P < 0.05; **P < 0.01; ****P < 0.0001; P-values were calculated by Student’s t-test.

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