Fig. 5: CircCOG2 promotes CRC proliferation, migration, and invasion via the miR1305/TGF-β2 pathway. | Cell Death Discovery

Fig. 5: CircCOG2 promotes CRC proliferation, migration, and invasion via the miR1305/TGF-β2 pathway.

From: Exosome-transmitted circCOG2 promotes colorectal cancer progression via miR-1305/TGF-β2/SMAD3 pathway

Fig. 5

A The illustration of dual luciferase reporter plasmid. B The luciferase activity of TGF-β2-WT or TGF-β2-MUT transfected with miR-1305 or miR-NC. C The expression of TGF-β2 was negatively correlated with miR-1305. D Represent imagines for IHC of TGF-β2 in circCOG2 high/low expression group and their IHC score. E–H CCK-8 and colony assays indicated that the TGF-β2 inhibitor rescued the pro-proliferation effect of circCOG2. I–L Transwell assay indicated that TGF-β2 inhibitor rescued the pro-invasion and pro-migration effect of circCOG2. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001; P-values were calculated by Student’s t-test.

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