Fig. 8: A variety of cytokines and drugs lead to an increased expression of RCN1. | Cell Death Discovery

Fig. 8: A variety of cytokines and drugs lead to an increased expression of RCN1.

From: RCN1 induces sorafenib resistance and malignancy in hepatocellular carcinoma by activating c-MYC signaling via the IRE1α–XBP1s pathway

Fig. 8

A qRT-PCR analysis showing the mRNA levels of RCN1 in Huh7 and HepG2 cells cultured with or without CAFs-CM (NC: negative control) for 48 h. B qRT-PCR results showing the mRNA expression of RCN1 in Huh7 and HepG2 cells in response to 25 ng/ml and 50 ng/ml of TNFα treatment for 24 h. C, D RCN1 mRNA is overexpressed after increased doses of lenvatinib and. regorafenib. E Schematic model. The tumor microenvironment and a variety of drugs can. promote the expression of RCN1. Data are presented as the means ± SEM of three independent experiments. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001, t-test.

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