Fig. 3: NGF promoted and protected the spinal cord tissues, improving the recovery of locomotor function. | Cell Death Discovery

Fig. 3: NGF promoted and protected the spinal cord tissues, improving the recovery of locomotor function.

From: Nerve growth factor (NGF) with hypoxia response elements loaded by adeno-associated virus (AAV) combined with neural stem cells improve the spinal cord injury recovery

Fig. 3

A Images of spinal cords in Sham, SCI, CON-NSCs, 5HRE-NSCs, 5HRE-NGF-NSCs group. B Video images sequence of rats 2 months after operation. Impaired hindlimb function while crawling is apparently manifested by powerless weight support (calculated as torso height minus ground), leg-extensor spasms (calculated as spasm interval relative to each step cycle duration), slow steps (quantity of hind-limb plantar steps each step cycle of forefoot) and weak foot placement (caudal to behind hip). Hip (iliac crest), knee and ankle joints are indicated by dots and lines. The arrow shows foot movement. Scale bar = 20 mm. C–E ** signifies P < 0.01 versus the SCI group, ## signifies P < 0.01 versus the NGF-NSCs group. Data are the mean values ± SD, n = 6.

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