Fig. 7: The tumor suppressor effect caused by TMEM161B-AS1 knockout was mediated by hsa-miR-27a-3p. | Cell Death Discovery

Fig. 7: The tumor suppressor effect caused by TMEM161B-AS1 knockout was mediated by hsa-miR-27a-3p.

From: Over-expression of lncRNA TMEM161B-AS1 promotes the malignant biological behavior of glioma cells and the resistance to temozolomide via up-regulating the expression of multiple ferroptosis-related genes by sponging hsa-miR-27a-3p

Fig. 7

a, b The hsa-miR-27a-3p, TMEM161B-AS1 expression level in U87 cells and U251 cells transfected by no template control (NC), si-TMEM161B-AS1 + hsa-miR-27a-3p antagomir, hsa-miR-27a-3p antagomir, si-TMEM161B-AS1 were detected by qRT-PCR. c, d Comparison of cell viability of U87 cells and U251 cells after transfected with NC, si-TMEM161B-AS1 + hsa-miR-27a-3p antagomir, hsa-miR-27a-3p antagomir, and si-TMEM161B-AS1. e, f Comparison of cell migration and invasion ability of U87 cells and U251 cells after transfected with NC, si-TMEM161B-AS1 + hsa-miR-27a-3p antagomir, hsa-miR-27a-3p antagomir, si-TMEM161B-AS1. g. Comparison of apoptosis rate of U87 cells and U251 cells after transfection of NC, si-TMEM161B-AS1 + hsa-miR-27a-3p antagomir, hsa-miR-27a-3p antagomir, si-TMEM161B-AS1. *p < 0.05, compared with NC, **p < 0.01, compared with NC. n = 3 per group.

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