Fig. 1: Cholesterol depletion alters mRNA levels of a large number of genes, including cholesterol homeostasis genes. | Cell Death Discovery

Fig. 1: Cholesterol depletion alters mRNA levels of a large number of genes, including cholesterol homeostasis genes.

From: Autophagy is induced and modulated by cholesterol depletion through transcription of autophagy-related genes and attenuation of flux

Fig. 1

Mv1Lu cells were treated (or not) by statin in the presence of mevalonate and LPDS (16 h) to reduce their cholesterol level, and then subjected to RNA-Seq (see “Materials and methods”). A Volcano plot depicts genes with significantly increased or reduced expression levels following CD relative to untreated cells. B Heat map of differentially expressed genes related to cholesterol homeostasis. Only those genes with significant differential expression (FDR < 0.05) are shown.

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