Fig. 3: Tubular NLRP3 upregulation associated with the renal maladaptive repair, and correlated with inflammation and fibrosis. | Cell Death Discovery

Fig. 3: Tubular NLRP3 upregulation associated with the renal maladaptive repair, and correlated with inflammation and fibrosis.

From: NLRP3 associated with chronic kidney disease progression after ischemia/reperfusion-induced acute kidney injury

Fig. 3

a Representative images of co-immunofluorescence staining of NLRP3 (red) and E-cadherin (green) in kidney section at chronic phase following AKI. b Representative images of cortex stained with HE. c Representative images of cortex stained with Masson trichrome. d Representative images of immunohistochemistry stain of F4/80 in kidney section. e Analysis and semi-quantification of Masson trichome evaluated by area scoring. f semi-quantification of F4/80-positive cells in per kidney section. g Correlation analysis of NLRP3-positive tubules with Masson trichome score (r = 0.8162) and F4/80-positive cells (r = 0.7956). 0.5 ≤ |r| < 0.8 defined as Moderately correlated. n = 3 mice for the sham group, n = 5 for mild and severe AKI per time-point group, respectively. Data are mean ± SD. ****P < 0.0001. a–d Bar = 20 mm.

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