Fig. 1: HMGA1 is frequently upregulated in CAAs and is correlated with a poor prognosis.
From: Overexpression of HMGA1 confers radioresistance by transactivating RAD51 in cholangiocarcinoma
A–C Expression analysis of HMGA1 in TCGA CAA, GSE76297 and Qilu hospital cohorts. D Representative images of immunohistochemical (IHC) staining of HMGA1 in our tissue microarray (containing 93 samples of CCA tissues collected from Qilu Hospital, Shandong University). E Statistical analysis of HMGA1 expression from IHC staining of our tissue microarray. High and low expression indicate the final score of each sample determined by two pathologists based on the intensity and extent of staining across the tissue microarray section. CCA patients were dichotomized into low (Score < 7) and high (Score ≧ 7) HMGA1 protein expression groups based on the IHC staining score. The high and low expression groups were separated based on the best cutoff. F Kaplan–Meier analysis of the correlation between HMGA1 expression and clinical prognosis based on data from our tissue microarray. G, H Kaplan–Meier analysis of the correlation between HMGA1 expression and the clinical prognosis (http://gepia.cancer-pku.cn/index.html). P-values were obtained by Student’s t test (A–C, H, I) or log-rank test (D–F). *P < 0.05, **P < 0.01, ***P < 0.001.
