Fig. 3: HMGA1 promotes tumorigenesis and progression of CCA in nude mouse xenografts.
From: Overexpression of HMGA1 confers radioresistance by transactivating RAD51 in cholangiocarcinoma
A, B Images of xenograft tumors, tumor mass, and tumor volume in mice subcutaneously injected with HUCCT1 cells with HMGA1 knockdown compared to the corresponding control (n = 5 mice per group). C Representative images of HE staining and IHC staining for HMGA1 and Ki-67 in HUCCT1 cell xenograft tumors. D, E Images of xenograft tumors, tumor mass, and tumor volume in mice subcutaneously injected with HUCCT1 cells with HMGA1 overexpression compared to the corresponding control (n = 5 mice per group). F Representative images of HE staining and IHC staining for HMGA1 and Ki-67 in HUCCT1 cell xenograft tumors. G, H Images of xenograft tumors, tumor mass, and tumor volume in mice subcutaneously injected with QBC939 cells with HMGA1 knockdown compared to the corresponding control (n = 6 mice per group). I Representative images of HE staining and IHC staining for HMGA1 and Ki-67 in QBC939 cell xenograft tumors. J, K Images of xenograft tumors, tumor mass, and tumor volume in mice subcutaneously injected with QBC939 cells with HMGA1 overexpression compared to the corresponding control (n = 5 mice per group). L Representative images of HE staining and IHC staining for HMGA1 and Ki-67 in QBC939 cell xenograft tumors. The P-value was obtained by Student’s t test. The results represent the mean ± S.D. *P < 0.05, **P < 0.01, ***P < 0.001.
