Fig. 2: Wip1 knockout impaired the therapeutic efficacy of MSCs in T1DM mice. | Cell Death Discovery

Fig. 2: Wip1 knockout impaired the therapeutic efficacy of MSCs in T1DM mice.

From: Wip1 regulates the immunomodulatory effects of murine mesenchymal stem cells in type 1 diabetes mellitus via targeting IFN-α/BST2

Fig. 2

A The body size of mice after infusion of Wip1+/+MSCs and Wip1−/− MSCs. B, C The blood glucose and the weight curves. D, E Pathological damages in pancreatic tissue by H&E staining and immunohistochemical staining. F, G The islet area and the mean density of insulin-positive cells in pancreatic tissues treated with Wip1−/− MSCs were smaller than that of the Wip1+/+MSCs group. (n = 8, three independent experiments), #P < 0.05, *P < 0.05, **P < 0.01.

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