Fig. 6: IFN-α secreted by Wip1−/−MSCs enhanced the inflammatory response in the pancreatic microenvironments of T1DM mice. | Cell Death Discovery

Fig. 6: IFN-α secreted by Wip1−/−MSCs enhanced the inflammatory response in the pancreatic microenvironments of T1DM mice.

From: Wip1 regulates the immunomodulatory effects of murine mesenchymal stem cells in type 1 diabetes mellitus via targeting IFN-α/BST2

Fig. 6

A Immunofluorescence staining of pancreatic microenvironment including insulin (green), MSCs (red), and nuclei (blue) showed the size change of insulin and homing of MSCs in T1DM mice with an infusion of Wip1+/+MSCs and Wip1−/−MSCs. B, C Expression of IFN-α, TNF-α, IL-17a, IL-4, and IL-10 in the pancreas by ELISA. Scale bar, 20 μm. (n = 7, three independent experiments) ns, not significant, *P < 0.05, **P < 0.01.

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