Fig. 2: LPS-induced macrophage EVs cause liver damage. | Cell Death Discovery

Fig. 2: LPS-induced macrophage EVs cause liver damage.

From: LPS-induced macrophage HMGB1-loaded extracellular vesicles trigger hepatocyte pyroptosis by activating the NLRP3 inflammasome

Fig. 2

a–d The EVs HMGB1 in sepsis patients serum were correlated with the levels of ALT (alanine aminotransferase), AST (aspartate aminotransferase), CRP (C-reactive protein), and Pct (procalcitonin). n = 5 mice per group. e MPO (myeloperoxidase) staining in the liver of all groups; Scale bar = 200 μm. f–h Serum ALT, AST and LDH (lactate dehydrogenase) levels in all groups. n = 5 mice per group. (*) P < 0.01 versus control group; (&) P < 0.01 versus LPS group; (#) P < 0.01 versus clodronate group.

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