Fig. 4: MMP1 promoted the phosphorylation of Erk1/2 and Akt.
From: Tumor-associated macrophages (TAMs) depend on MMP1 for their cancer-promoting role
A, C Western blotting analysis for PI3K/Akt and MAPK/Erk signaling in HT-29 and Caco-2 cells treated with 0, 25, 50, and 75% TAMs-CM (A) or 0, 10, 50, 100 μg/ml rhMMP1 (C). B, D Comparison of the protein levels in HT-29 and Caco-2 cells treated with 0, 25, 50, and 75% TAMs-CM (B) or 0, 10, 50, 100 μg/ml rhMMP1 (D). All data are presented as the mean ± SD from three independent experiments. *P < 0.05.
