Fig. 6: Essential role of MMP1/PAR1/Erk1/2 axis in tumor formation of colon cancer cells.
From: Tumor-associated macrophages (TAMs) depend on MMP1 for their cancer-promoting role
A Schematic representation of the tumor xenografts formed by TAMs and HT-29 cells cells with PAR1 inhibitor MK-5348 or Erk1/2 inhibitor SCH772984. B, C Tumor growth curves (B) and tumor weights (C) for tumor xenograft formed by TAMs and HT-29 cells cells with MK-5348 or SCH772984. D IHC staining for Ki67 in tumor xenografts formed by TAMs and HT-29 cells cells with MK-5348 or SCH772984. E Comparison of immunoreactivity scores (IRS) of Ki67 among the five group. *P < 0.05.
