Fig. 4: NEDD4L was identified as ubiquitin ligase for CPNE1. | Cell Death Discovery

Fig. 4: NEDD4L was identified as ubiquitin ligase for CPNE1.

From: The regulation of CPNE1 ubiquitination by the NEDD4L is involved in the pathogenesis of non-small cell lung cancer

Fig. 4

A Network view of the predicted E3 ligases for CPNE1 from Ubi-Browser. B NEDD4L expression is downregulated in multiple types of human cancer. C Low-level expression of NEDD4L is correlated with poor prognosis in lung cancer. D, E The mRNA levels of CPNE1 and NEDD4L are unrelated in non-small cell lung cancer. F Western blot analysis of CPNE1 and NEDD4L protein levels in 14 randomly selected NSCLC tissues and paired noncancerous lung tissues. The band density ratios represent the relative expression levels of CPNE1 and NEDD4L. G Relative protein expression levels of CPNE1 and NEDD4L in 14 paired NSCLC tissues. The Y-axis indicates the log10 transformed fold change in the T/N protein expression ratios of CPNE1 and NEDD4L. The number of each specimen is indicated below the X-axis.

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