Fig. 6: NEDD4L knockout promotes tumor cell proliferation and metastasis through CPNE1. | Cell Death Discovery

Fig. 6: NEDD4L knockout promotes tumor cell proliferation and metastasis through CPNE1.

From: The regulation of CPNE1 ubiquitination by the NEDD4L is involved in the pathogenesis of non-small cell lung cancer

Fig. 6

A CPNE1 protein levels in NEDD4L-KO/NEDD4L-KO NSCLC cells and NSCLC cells with CPNE1 interference. B CCK-8 assay of cell viability in A549 cells. C Representative images showing the results of clonogenic assays of cell proliferation in A549 cells. Bar charts showing the colony formation of cells. D Flow cytometric assay of A549 cells. Cells were harvested 72 h after transfection and stained with PI. The percentage of cells in each cell cycle phase is shown in the inset of each panel. E Representative images showing the results of transwell cell migration and invasion assays in A549 cells. **P < 0.01; ***P < 0.001.

Back to article page