Fig. 4: Axdnd1−/− mice display progressive germ cell loss during spermiogenesis.
From: AXDND1, a novel testis-enriched gene, is required for spermiogenesis and male fertility
A Representative images of seminiferous tubules at various stages from adult WT and Axdnd1−/− male mice are shown. Disorganized germ cells and reduced late spermatids were observed in Axdnd1−/− male mice. Scale bar: 100 µm. B Statistical analysis of the ratio of spermatids to the number of Sertoli cells during spermiogenesis (from steps 1–16). Significant loss of step 9–16 spermatids occurred in Axdnd1−/− male mice during the later-half phase of spermiogenesis. Data are presented as Mean ± SEM, n = 3. *P < 0.05 by Student’s t-test.
