Fig. 3: MAPK pathways activation in the retina after 24 h from C57BL/6J mice eye removal. | Cell Death Discovery

Fig. 3: MAPK pathways activation in the retina after 24 h from C57BL/6J mice eye removal.

From: Retinal ganglion cell loss in an ex vivo mouse model of optic nerve cut is prevented by curcumin treatment

Fig. 3

A–D Representative western blots and relative quantifications showed the significant higher p-JNK/JNK (A), p-c-Jun/c-Jun (B), and p-Tau/Tau (D) ratios in retina homogenates collected at time 24 in comparison to time 0, while the p-ERK/ERK (C) ratio was lower. E Representative western blots and relative quantifications showed the significant higher SUMO-1 and UBC9 level in retina homogenates collected at time 24 in comparison to time 0. F Representative western blots and relative quantifications showed the significant time-dependent decrease of the ubiquitin level and increase of the LC3B level expressed as the LC3BII/I ratio in retina homogenates collected at time 24 in comparison to time 0. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001 [n = 5]. Data were expressed as mean ± SEM. One-way ANOVA, Tukey’s post hoc test.

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