Fig. 1: BBR alleviates liver fibrosis in mice. | Cell Death Discovery

Fig. 1: BBR alleviates liver fibrosis in mice.

From: Berberine alleviates liver fibrosis through inducing ferrous redox to activate ROS-mediated hepatic stellate cells ferroptosis

Fig. 1

Mice were divided into: Control group (Ctrl, only i.p. with saline or oil, respectively), Berberine group (BBR, BBR 200 mg/kg/day intragastrically and i.p. with saline or oil, respectively), Liver fibrosis model group (TAA or CCl4, TAA/CCl4-induced hepatic fibrotic, i.p. with TAA or CCl4, respectively), and TAA- or CCl4-treated group plus BBR (TAA + BBR or CCl4 + BBR). A, B General examination of TAA/CCl4-induced mouse liver fibrosis by H&E, Masson’s trichrome, and Sirius red staining. C, D Vimentin and α-SMA are represented in TAA/CCl4-induced mouse liver fibrosis. E, F Protein expression of Vimentin and α-SMA in TAA/CCl4-induced mouse liver fibrosis. G Determination of serum hyaluronic acid. H Determination of serum ALT and AST. The results are expressed as mean ± SD. Data are representative of three independent experiments; n = 6 in every group; Scales: 1 cm or 100 μm. Representative photographs are shown. Compared with the control group, **P < 0.01; compared with the model group, ##P < 0.01.

Back to article page