Fig. 4: Cytosolic mtDNA exacerbated inflammatory progression. | Cell Death Discovery

Fig. 4: Cytosolic mtDNA exacerbated inflammatory progression.

From: Mitochondrial DNA leakage exacerbates odontoblast inflammation through gasdermin D-mediated pyroptosis

Fig. 4

A The mRNA level of inflammatory cytokines, CXCL10 and IFN-β was detected by qPCR after overexpressing mtDNA (1 μg/well). B qPCR was performed to assess the CXCL10 and IFN-β mRNA level in mDPC6T cells after EtBr (1 μg/ml, 48 h) and LPS (20 μg/ml, 24 h) treatment. The data are the means ± standard deviations of three independent experiments (p < 0.05*, p < 0.01**, p < 0.001***).

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