Fig. 6: TRAP1 protected cardiac function and mitochondrial cristae of rats’ heart by increasing MIC60 protein levels in extracellular acidosis. | Cell Death Discovery

Fig. 6: TRAP1 protected cardiac function and mitochondrial cristae of rats’ heart by increasing MIC60 protein levels in extracellular acidosis.

From: TRAP1 inhibits MIC60 ubiquitination to mitigate the injury of cardiomyocytes and protect mitochondria in extracellular acidosis

Fig. 6

A Transmission electron microscopy was used to detect the ultrastructure of mitochondria of rats’ heart tissue. Twenty-five images were obtained from five rats for each group. The average cristae number in one mitochondrion (n = 30 mitochondria for each group randomly selected from 25 pictures) of each group was quantified. B HE staining was used to detect tissue injury of rats’ heart tissue. C Echocardiography was used to detect cardiac functions of rats including LVEF. D–E Elisa assay was used to detect serum BNP (D) and cTnI (E). Data were the means ± SD from six rats. Group comparisons were performed by one-way analysis of variance followed by Tukey’s post hoc test. &P < 0.05 vs. Normal group. *P < 0.05 vs. sh-Con group. #P < 0.05 vs. ov-Con group. ψP < 0.05 vs. ov-TRAP1 group or ov-MIC60 group.

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