Fig. 1: UBQLN4 is upregulated in CRC tissues and related to a poor prognosis. | Cell Death Discovery

Fig. 1: UBQLN4 is upregulated in CRC tissues and related to a poor prognosis.

From: UBQLN4 is activated by C/EBPβ and exerts oncogenic effects on colorectal cancer via the Wnt/β-catenin signaling pathway

Fig. 1

A TCGA database analysis showed significantly higher UBQLN4 expression in CRC tissues (n = 568) than in ANTs (n = 44) (p < 0.001). B The fold changes (log2) in UBQLN4 expression in 50 paired CRC tissues compared with ANTs detected using RT-qPCR. C Based on the fold changes in UBQLN4 expression, 50 paired CRC tissue samples were split into two groups. D The correlation between UBQLN4 expression and tumor stage. E UBQLN4 protein expression was examined in four paired CRC tissue samples using western blot. F Representative images of UBQLN4 IHC staining in CRC tissues and ANTs. Upper: 100×, scale bar: 250 μm. Lower: 200×, scale bar: 100 μm. G UBQLN4 expression was detected using RT-qPCR in FHC, SW480, DLD-1, HCT-116, and HCT-8 cells. H, I Kaplan–Meier OS and DFS curves showed that patients with higher UBQLN4 expression had shorter survival times. J ROC curves were used to estimate the diagnostic efficacy of UBQLN4 expression for CRC. All data from at least three independent experiments are presented as the means ± SD. *p < 0.05, **p < 0.01, *** or ****p < 0.001.

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