Fig. 5: UBQLN4 exerts oncogenic effects by activating the Wnt/β-catenin signaling pathway. | Cell Death Discovery

Fig. 5: UBQLN4 exerts oncogenic effects by activating the Wnt/β-catenin signaling pathway.

From: UBQLN4 is activated by C/EBPβ and exerts oncogenic effects on colorectal cancer via the Wnt/β-catenin signaling pathway

Fig. 5

A–I The top 9 pathways enriched in the high UBQLN4 expression phenotype (sorted by NES). J The correlations between the expression of UBQLN4 and β-catenin and UBQLN4 and c-Myc (Data were obtained from GEO database, GSE131418). K–O Western blot experiment indicated that UBQLN4 overexpression increased the expression of β-catenin and c-Myc, while UBQLN4 knockdown reduced the expression of β-catenin and c-Myc. P The correlation levels between C/EBPβ and UBQLN4, C/EBPβ and c-Myc, and C/EBPβ and β-catenin (Data were obtained from GEO database, GSE131418). Q Western blot showed that C/EBPβ overexpression increased β-catenin and c-Myc levels in both HCT-8 and SW480 cells. All data from at least three independent experiments are presented as the means ± SD. *p < 0.05, **p < 0.01, *** or ****p < 0.001.

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