Fig. 7: Downregulation of UBQLN4 inhibits CRC growth in vivo. | Cell Death Discovery

Fig. 7: Downregulation of UBQLN4 inhibits CRC growth in vivo.

From: UBQLN4 is activated by C/EBPβ and exerts oncogenic effects on colorectal cancer via the Wnt/β-catenin signaling pathway

Fig. 7

A The size of xenograft tumors after harvest. B The growth curve of xenograft tumors from tumor formation to sacrifice in mice. C The weight of xenograft tumors after harvest. D–H IHC staining of xenograft tumors indicated that the LV-Si-UBQLN4 group showed lower UBQLN4, β-catenin, c-Myc and Ki67 expression than the LV-NC group. Left: 100×, scale bar: 100 μm. Right: 200×, scale bar: 50 μm. I Schematic illustration of the UBQLN4 molecular mechanism in CRC. All data from at least three independent experiments are presented as the means ± SD. *p < 0.05, **p < 0.01, *** or ****p < 0.001.

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