Fig. 2: 4-OI inhibits ferroptosis in murine lung during sepsis-induced ALI. | Cell Death Discovery

Fig. 2: 4-OI inhibits ferroptosis in murine lung during sepsis-induced ALI.

From: Itaconate inhibits ferroptosis of macrophage via Nrf2 pathways against sepsis-induced acute lung injury

Fig. 2

A Heatmap of selected ferroptosis associated genes in macrophage between LPS and Itaconate + LPS (4 h) group. B Western blots for GPX4 and PTGS2 in murine lung tissue. C, D Relative mRNA levels of GPX4 and PTGS2 in murine lung tissue (n = 6). E, F Relative iron and MDA levels of murine lung tissue (n = 6). G Representative images of immunohistochemistry staining for 4-HNE in murine lung tissue. (Data are presented as Mean ± SD *p < 0.05, **p < 0.01, ***p < 0.001).

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