Fig. 5: BIN1 is a direct target of miR-200a-3p in EOC cells. | Cell Death Discovery

Fig. 5: BIN1 is a direct target of miR-200a-3p in EOC cells.

From: Long non-coding RNA SNHG10 upregulates BIN1 to suppress the tumorigenesis and epithelial–mesenchymal transition of epithelial ovarian cancer via sponging miR-200a-3p

Fig. 5

A BIN1 was contained in the overlapped result from the bioinformatic algorithm PITA, miRanDa and miRWALK. B The predicted binding between miR-200a-3p and BIN1-3’-UTR. C The sequences of BIN1-3’-UTR-WT and BIN1-3’-UTR-MUT. D miR-200-3p mimic decreased the luciferase activity of EOC cells transfected with BIN1-3’-UTR-WT but not in the cells transfected with BIN1-3’-UTR-MUT. E The miR-200a-3p inhibitor increased the expression of BIN1 mRNA in EOC cells. F The miR-200a-3p inhibitor increased the expression of BIN1 mRNA in EOC cells. The experiments were conducted in triplicate.

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