Fig. 6: LINC00858 promotes the tumorigenicity of colon cancer cells in mice by regulating the RAD21/PCNP/STAT3/5 axis. | Cell Death Discovery

Fig. 6: LINC00858 promotes the tumorigenicity of colon cancer cells in mice by regulating the RAD21/PCNP/STAT3/5 axis.

From: LINC00858 promotes colon cancer progression through activation of STAT3/5 signaling by recruiting transcription factor RAD21 to upregulate PCNP

Fig. 6

A The expression of LINC00858 in tumor tissues determined by RT-qPCR. B The expression of RAD21, PCNP, STAT3, and STAT5, and phosphorylation levels of STAT3 and STAT5 in tumor tissues detected by Western blot assay. Histogram depicting the result of gray value analysis, and the numerical value is the expression value relative to the internal parameters. C Representative images of xenografts in nude mice on day 35 of SW480 cell inoculation and the tumor volume of each group. D The tumor weight in each group of nude mice. *p < 0.05. Data from multiple groups were compared using one-way ANOVA with Tukey’s post hoc tests. Repeated measures ANOVA with Bonferroni’s post hoc test was used to compare the data obtained at different time points. n = 6.

Back to article page