Fig. 7: Schematic diagram of the mechanism by which LINC00858 affects colon cancer. | Cell Death Discovery

Fig. 7: Schematic diagram of the mechanism by which LINC00858 affects colon cancer.

From: LINC00858 promotes colon cancer progression through activation of STAT3/5 signaling by recruiting transcription factor RAD21 to upregulate PCNP

Fig. 7

LINC00858 can recruit the transcription factor RAD21, which in turn binds to the PCNP promoter to promote PCNP transcription and expression, thereby activating the STAT3/5 signaling pathway, promoting the proliferation, migration, and invasion of colon cancer cells, inhibiting their apoptosis, and ultimately promoting colon cancer progression.

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