Fig. 5: SP600125 effectively attenuated disease activity in PIL mice. | Cell Death Discovery

Fig. 5: SP600125 effectively attenuated disease activity in PIL mice.

From: Blocking GSDME-mediated pyroptosis in renal tubular epithelial cells alleviates disease activity in lupus mice

Fig. 5

A Albustix test papers were used to determine urinary protein levels. Urine protein scores were measured once every two weeks. B, E The levels of autoantibodies (anti-dsDNA and anti-Sm antibodies) and cytokines (IL-6 and TNF-α) were examined by ELISA. C Representative H&E staining of glomerular and renal tubular lesions in kidneys is shown (left). Austin scores of kidneys were determined (right). D Immunofluorescence analysis showing IgG deposition in the kidney. The data are shown as the mean ± SD, *p < 0.05, **p < 0.01, ***p < 0.001.

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