Fig. 2: Identification of differentially succinylated proteins between DR and IMH. | Cell Death Discovery

Fig. 2: Identification of differentially succinylated proteins between DR and IMH.

From: Sirt5-mediated desuccinylation of OPTN protects retinal ganglion cells from autophagic flux blockade in diabetic retinopathy

Fig. 2

A The number of differentially succinylated proteins or modification sites between the DR and IMH groups. Quantitative data with a p value < 0.05 and ratio >1.5 or <0.667 were considered differential succinylation. B Volcano plot of differentially succinylated modification sites between the DR and IMH groups. C Histogram of GO enrichment analyses based on the cellular component, molecular function and biological process categories of differentially succinylated proteins. D MS spectrum of the succinylated OPTN K108 site. E The K108 site is highly conserved in different species, ranging from mice to humans. DR diabetic retinopathy, IMH idiopathic macular hole, GO Gene Ontology, K lysine.

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