Fig. 4: Trim33 can promote the ubiquitination of activated zymogen.

A Co-localization analysis of endogenous ubiquitin and zymogen particles, showing DAPI-labeled nucleus, green fluorescein-labeled ubiquitin antibody, red fluorescein-labeled trypsin, and yellow fluorescence represents the co-localization of ubiquitin and activated zymogen; B the relative intensity of yellow fluorescence in each group (t-test, ***p < 0.001).